Scientists find gene link to teenage binge drinking












LONDON (Reuters) – Scientists have unpicked the brain processes involved in teenage alcohol abuse and say their findings help explain why some young people have more of a tendency to binge drink.


A study published in the Proceedings of National Academy of Sciences (PNAS) journal found that a gene known as RASGRF-2 plays a crucial role in controlling how alcohol stimulates the brain to release dopamine, triggering feelings of reward.












“If people have a genetic variation of the RASGRF-2 gene, alcohol gives them a stronger sense of reward, making them more likely to be heavy drinkers,” said Gunter Schumann, who led the study at King’s College London’s Institute of Psychiatry.


Alcohol and other addictive drugs activate the brain’s dopamine systems, which induces feelings of pleasure and reward.


Worldwide, some 2.5 million people die each year from the harmful use of alcohol, accounting for about 3.8 percent of all deaths, according to the World Health Organisation.


Recent studies also carried out by scientists at the IoP have found that RASGRF-2 is a risk gene for alcohol abuse, but until now the mechanism involved in the process was not clear.


For this study, scientists initially looked at mice who had been modified to have the RASGRF2 gene removed, to see how they reacted to alcohol. They found the lack of RASGRF-2 was linked to a significant reduction in alcohol-seeking activity.


They also discovered that when the mice did consume alcohol, the absence of RASGRF-2 reduced the activity of dopamine-releasing neurons in a region of the brain called the ventral tegmental area (VTA) – preventing the brain from releasing dopamine and limiting any sense of reward.


The team then analyzed brain scans of 663 14-year old boys and found that when they were anticipating a reward in a mental test, those with genetic variations to the RASGRF2 gene had more activity in an area of the brain closely linked to the VTA and also involved in dopamine release.


This suggests people with a genetic variation on the RASGRF-2 gene release more dopamine when anticipating a reward, and hence derive more pleasure from it, the scientists said.


To confirm the findings, the team analyzed drinking behavior from the same group of boys two years later when many of them had already begun drinking frequently.


They found that those with the RASGRF-2 gene variation drank more often at the age of 16 than those without it.


“People seek out situations which fulfill their sense of reward and make them happy, so if your brain is wired to find alcohol rewarding, you will seek it out,” Schumann said in a statement about the research. “We now understand the chain of action: how our genes shape this function in our brains and how that, in turn, leads to human behavior.”


Experts writing in The Lancet journal in February said up to 210,000 people in England and Wales will be killed prematurely by alcohol in the next 20 years, with a third of those preventable deaths due to liver disease alone.


(Reporting by Kate Kelland)


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Does the GOP need a religious retreat?


(Photo by Brandon Thibodeaux/Getty Images)


It's no surprise that Florida Sen. Marco Rubio took heat for an interview he gave to GQ magazine this month: Departing from scientific consensus, the rising Republican star refused to state whether the Earth is billions of years old or a few thousand, as many fundamentalist Christians believe.


What no one expected was the rebuke from televangelist and longtime Christian conservative leader Pat Robertson, dismissing theories of a "young Earth."


"If you fight science, you are going to lose your children," Robertson said last week during an appearance on the Christian Broadcast Network, the television empire he founded three decades ago.


Robertson wasn't directly speaking to Rubio, but the senator and others in his party might heed the advice. Viewed by many voters as anti-science and too conservative on social issues such as gay marriage, the Republican Party is in danger of losing young and less religious voters for years to come.


In a post-election breakdown by the Public Religion Research Institute, the Obama religious coalition mirrors the demographics of 18-29 year olds, whereas Romney's mirrors those of voters aged 65 and up.


On Nov. 6, as President Barack Obama won a narrow but clear victory over Mitt Romney, voters in four states expressed support for gay marriage. Anti-abortion candidates lost in several states, including Senate contenders Todd Akin of Missouri and Richard Mourdock of Indiana, both of whom stirred outrage from their remarks on rape.


Many experts believe these developments point in part to a decisive shift in the religious makeup of the country, one that could make or break a GOP comeback.


"The way Republicans speak is turning off the youngest, fastest growing groups in the country—Latinos and significantly, the unchurched, those with no religious affiliation," said Mark Rozell, a public policy professor at George Mason University who studies religion and politics. "To them, the Republicans are proselytizing."


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Since the 1980s, organizations like Focus on the Family, the Moral Majority and the Christian Coalition cemented religious conservatives as visible and potent force in the Republican coalition and enforced discipline on social issues such as abortion and gay rights. But now, the religious landscape is changing beneath their feet.


Studies suggest the number of unchurched has doubled in the past two decades and shot up by 25 percent in the last four years. The shift has taken place across the country and across economic classes, most notably among the young; one fifth of adults and one third of Americans under thirty now declare themselves religiously unaffiliated.


The new and expanding group of unchurched voters overwhelmingly support same sex-marriage and legal abortion, and so they gravitate toward the Democratic Party.


"It's clearly a concern—we have a lot of work to do," said Gary Marx, executive director of the Faith and Freedom Coalition, which worked to boost turnout among Catholics and evangelical voters.


The group, founded by conservative Christian activist Ralph Reed, helped deliver more religious voters to the polls this year than in 2008, but such efforts couldn't deliver a Romney victory.


In a press release following the election, Reed acknowledged that minorities and the young—and therefore, he might have added, the unchurched—made the difference for Obama.


Marx and his colleagues insist they aren't especially concerned about the growing secularization of young voters. They are primarily looking to diversify the GOP's religious coalition, Marx said.


To close the Latino gap, Marx says conservative activists are planning a major outreach effort to evangelical Hispanics and to Hispanic Catholics who attend Mass.


"We are casting a wider net—the politics of addition, not subtraction," Marx said, adding that Latinos and other minorities have been attracted to many conservative positions like education reform.


Marx pointed to Georgia, where Hispanic and black voters supported a state amendment allowing the state government to set up charter schools.


Marx also suggested the Democratic advantage with young minority voters was "candidate-centric" — a reflection of Obama's unique status as the first black president.


But the problem may run deeper, into the Republican base: There is growing evidence that young evangelicals are simply less interested in politicizing hot-button issues.


"Young evangelicals don't look at the country as a battlefield, but rather a mission field," says James Wilcox, a George Mason University political science professor. "They're are less scared than their forbearers: They see the 'War on Religion' narrative as nonsense; they see churches thriving, the outlets they have, and the extent of religious pluralism in this country."


The new generation sees community activism, rather than electoral politics, as the means for their faith to shape the world, Wilcox argues. They may disagree with liberals about same-sex marriage, but they also believe that states have the right to determine such policies.


Many younger evangelicals are also serious about addressing climate change, even as many high-profile conservatives have expressed doubt about whether climate change is real—with nominee Mitt Romney cracking jokes about it at this year's Republican National Convention.


None of this means the influence of religious conservatives on Republican politics is set to disappear. But it is most certainly about to change.


Between the rise of the unchurched and the moderation of young religious conservatives, experts say, a smaller movement may emerge — one that retains its current zeal but carries less sway over the selection of GOP nominees. Or the movement could retain its power by successfully diversifying and coming up with a new way to talk to voters.


"We plan to reach out with a softer, pro-family agenda—less emphasis on the sexual points, more talk about family," Marx of the Faith and Freedom Coalition said. He also said activists would develop a "forward-looking" policy agenda akin to President George W. Bush's "compassionate conservatism."


But at the same time, Marx believes that some of that message already has been lifted by social liberals: "It is true that gay rights activists have stolen that language of 'family' we've used successfully, and now use it for their purposes."


One way for religious conservatives to start again, Rozell said, would be to return the favor and take a tip from two much-heralded communicators: Presidents Ronald Reagan and Bill Clinton.


"Successful politicians can speak two languages, even if it's hard to do," Rozell said. Reagan did it, addressing both the Christian right and a largely secular small-government audience. Often times it's a shift in rhetoric rather than policy."


Rozell cited Republican Gov. Bob McDonnell of Virginia, a strong social conservative, who has maintained his popularity by using language that appeals to both religious and secular audiences.


Another strategy would be to borrow from the vocabulary of the other team, as Bill Clinton did when he co-opted the rhetoric of religious conservatives to crack down on the culture of sex and violence on TV.


"Put aside this talk of wars," Rozell says, "Republicans could easily adopt the rhetoric of "rights" and "tolerance" that liberals currently own, to speak to secular types about the value of pluralism and religious conscience."



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Gunmen assassinate peasant leader in Paraguay












ASUNCION, Paraguay (AP) — Gunmen murdered one of the surviving leaders of a peasant movement whose land dispute with a powerful politician prompted the end of Fernando Lugo‘s presidency last June.


Vidal Vega, 48, was hit four times early Saturday by bullets from a 12-gauge shotgun and a .38-caliber revolver fired by two unidentified men who sped away on a motorcycle, according to an official report prepared at the police headquarters in the provincial capital of Curuguaty.












A friend, Mario Espinola, told The Associated Press that Vega was shot down when he stepped outside to feed his farm animals.


Vega was among the public faces of a commission of landless peasants from the settlement of Yby Pyta, which means Red Dirt in their native Guarani language.


He had lobbied the government for many years to redistribute some of the ranchland that Colorado Party Sen. Blas Riquelme began occupying in the 1960s.


By last May, the peasants finally lost patience and moved onto the land. A firefight during their eviction on June 15 killed 11 peasants and six police officers, prompting the Colorado Party and other leading parties to vote Lugo out of office for allegedly mismanaging the dispute.


Twelve suspects, nearly all of them peasants from Yby Pyta, have been jailed without formal charges since then on suspicion of murdering the officers, seizing property and resisting authority. The prosecutor had six months to develop the case and will present his findings Dec. 16.


Vega was expected to be a witness at the criminal trial, since he was among the few leaders who weren’t killed in the clash or jailed afterward.


He wasn’t charged because he was away getting supplies when the violence erupted at the settlement erected by the peasants inside Riquelme’s ranch, the Naranjaty Commission’s secretary, Martina Paredes, told the AP.


“We think he was assassinated by hit men who were sent, we don’t know by whom, perhaps to frighten us and frustrate our fight to recover the state lands that were illegally taken by Riquelme,” she said.


Riquelme, who died of natural causes about a month after the battle in June, occupied the land during the dictatorship of Alfredo Stroessner, whose government gave away land for free to anyone willing to put it to productive use.


A local court in Curuguaty upheld Riquelme’s claim to the land years later. Lugo’s government later sought to overturn the decision, but the case remains tied up in court.


Latin America News Headlines – Yahoo! News


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“Searching for Sugar Man” wins Producers Guild documentary nomination












LOS ANGELES (TheWrap.com) – “Searching for Sugar Man” is the best-known of the five films whose producers have been nominated for documentary motion pictures by Producers Guild of America, which announced its nominations on Friday.


Malik Bendjelloul’s film about the rediscovery of ’70s recording artist Rodriguez joined a slate of nominees that also includes Jon Shenk’s doc about the ousted president of the Maldives, “The Island President”; Marius A. Merkevicius‘ story of the 1992 Lithuanian Olympic basketball team, “The Other Dream Team”; Dror Moreh’s chronicle of some members of the Israeli intelligence services, “The Gatekeepers”; and Aaron Yeger’s film about the Roma (gypsies) in Europe, “A People Uncounted.”












The PGA bypassed number of the year’s high-profile docs, including “Bully,” “The Queen of Versailles,” “The Imposter,” “Samsara,” “West of Memphis” and “The Invisible War.”


Of the guild’s choices, only “Sugar Man” was also nominated in the top category at the IDA Awards and the Cinema Eye Honors, the two major awards in the documentary field.


The PGA release:


LOS ANGELES, CA (November 30, 2012) – The Producers Guild of America (PGA) announced today the Documentary Motion Picture nominees that will advance in the voting process for the 24th Annual Producers Guild Awards.


The nominated films, listed below in alphabetical order, are:


A PEOPLE UNCOUNTED


THE GATEKEEPERS


THE ISLAND PRESIDENT


THE OTHER DREAM TEAM


SEARCHING FOR SUGAR MAN


All other nominations for the 2013 Producers Guild Award categories will be announced on January 3, 2013, along with the individual producers.


All 2013 Producers Guild Award winners will be announced on January 26, 2013 at the Beverly Hilton Hotel. This year, the Producers Guild will also award special honors to Bob and Harvey Weinstein, J.J. Abrams, Tim Bevan and Eric Fellner and Russell Simmons, among others. The 2013 Producers Guild Awards Chair is Michael De Luca.


In 1990, the Producers Guild held the first-ever Golden Laurel Awards, which were renamed the Producers Guild Awards in 2002. Richard Zanuck and Lili Fini Zanuck took home the award for Best Produced Motion Picture for DRIVING MISS DAISY, establishing the Guild’s awards as a bellwether for the Oscars. Last year, the PGA awarded THE ARTIST with its Darryl F. Zanuck Producer of the Year Award in Theatrical Motion Pictures, marking the fifth consecutive year the Producers Guild has presaged the Academy of Motion Picture’s choice.


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Teens may buy less tobacco when displays are hidden












NEW YORK (Reuters Health) – A new study conducted using a virtual reality game suggests teens may be less likely to try to buy cigarettes at convenience stories if they aren’t sold in plain sight behind the counter.


Requiring stores to hide tobacco product displays is one option some states are considering to curb teen smoking after the Family Smoking Prevention and Tobacco Control Act of 2009 was passed, according to the study’s lead author.












“We know the retail environment is a very important place for tobacco companies to advertise and market their products,” said Annice Kim, from the independent research institute RTI International in Research Triangle Park, North Carolina.


“They’re prominently displayed at the point of sale, and it exposes all customers, including kids.”


Kim’s team wanted to test the effects of covering up such cigarette displays on teen shopping and opinion. But the researchers couldn’t conduct a real-world experiment because as of yet, no states have banned the displays.


So they designed a virtual reality game and sent more than 1,200 youth, between age 13 and 17, into a simulated online convenience store. Researchers asked the participants to select four items in the store: a snack from the aisles, a drink from the coolers and two products of their choice from the checkout counter.


In some scenarios, the cabinet behind the counter prominently displayed cigarettes, while other teens saw the cabinet closed and the display covered up.


Any teens that tried to ask the cashier for cigarettes were denied because of age – but what the researchers were interested in was how many asked.


Depending on other changes they made to the virtual convenience stores, the researchers found that 16 to 24 percent of teens tried to buy tobacco when the display was open, compared to 9 to 11 percent when it was closed.


In a post-virtual shopping survey, whether cigarettes were openly displayed wasn’t clearly tied to teens’ perceptions of how easy it would be to buy tobacco products if a similar store existed in their neighborhood.


However, 32 percent of youth said they were aware cigarettes were available for sale when the display case was closed in their virtual store, compared to 85 percent of those who had the open version, according to findings published Monday in Pediatrics.


“Policies that require retailers to store tobacco products out of view… could have a positive public health impact,” Kim told Reuters Health.


Still, she said this single study, funded by the New York State Department of Health, would have to be considered along with other evaluations of the display restrictions before making policy recommendations.


One tobacco control researcher not involved in the new study said he thinks there is “strong justification” for hiding cigarette displays from youth, but that this study doesn’t necessarily add much to that debate.


“It certainly shows that tobacco displays get people to think about cigarettes, which is what they’re for,” said Dr. Michael Siegel, from the Boston University School of Public Health.


But, “It can’t be extrapolated into real life, because in real life kids would go to a store when they want to buy cigarettes,” he told Reuters Health.


“I don’t know how many situations there are when a kid is hanging out in a convenience store with nothing to do and says, ‘Oh, I’ll just try a cigarette as long as they’re here.’”


Rather, he said, banning the displays could help prevent youth from being exposed to marketing by cigarette companies and influenced in their attitudes toward smoking.


SOURCE: http://bit.ly/cxXOG Pediatrics, online December 3, 2012.


Health News Headlines – Yahoo! News


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Italy votes for center-left candidate for premier












ROME (AP) — Italians are choosing a center-left candidate for premier for elections early next year, an important primary runoff given the main party is ahead in the polls against a center-right camp in utter chaos over whether Silvio Berlusconi will run again.


Sunday’s runoff pits a veteran center-left leader, Pier Luigi Bersani, 61, against the 37-year-old mayor of Florence, Matteo Renzi, who has campaigned on an Obama-style “Let’s change Italy now” mantra.












Nearly all polls show Bersani winning the primary, after he won the first round of balloting Nov. 25 with 44.9 percent of the vote. Since he didn’t get an absolute majority, he was forced into a runoff with Renzi, who garnered 35.5 percent.


After battling all week to get more voters to the polling stations for round two, Renzi seemed almost resigned to a Bersani win by Sunday, saying he hoped that by Monday “we can all work together.”


Bersani, a former transport and industry minister, seemed confident of victory as well, joking about Berlusconi’s flip-flopping political ambitions by asking “What time did he say it?” when told that the media mogul had purportedly decided against running.


Next year’s general election will largely decide how and whether Italy continues on the path to financial health charted by Premier Mario Monti, appointed last year to save Italy from a Greek-style debt crisis.


The former European commissioner was named to head a technical government after international markets lost confidence in then-Premier Berlusconi’s ability to reign in Italy’s public debt and push through sorely needed structural reforms.


Berlusconi has largely stayed out of the public spotlight for the past year, but he returned with force in recent weeks, announcing he was thinking about running again, then changing his mind, then threatening to bring down Monti’s government, and most recently staying silent about his political plans.


His waffling has thrown his People of Freedom party into disarray and disrupted its own plans for a primary — all of which has only seemed to bolster the impression of order, stability and organization within the center-left camp.


A poll published Friday gave the Democratic Party 30 percent of the vote if the election were held now, compared with some 19.5 percent for the upstart populist movement of comic Beppe Grillo, and Berlusconi’s People of Freedom party in third with 14.3 percent. The poll, by the SWG firm for state-run RAI 3, surveyed 5,000 voting-age adults by telephone between Nov. 26 and 28. It had a margin of error of plus or minus 1.36 percentage points.


It’s quite a turnabout for Berlusconi’s once-dominant movement, and a similarly remarkable shift in fortunes for the Democratic Party, which had been in shambles for years, unable to capitalize on Berlusconi’s professional and personal failings while he was premier.


But Berlusconi’s 2011 downfall and a series of recent political party funding scandals that have targeted mostly center-right politicians have contributed to the party’s rise as Italy struggles through a grinding recession and near-record high unemployment.


Angelino Alfano, Berlusconi’s hand-picked political heir, seemed again exasperated Sunday after a long meeting with his patron over Berlusconi’s plans. News reports have suggested Berlusconi might split the party in two and re-launch the Forza Italia party that brought him to political power for the first time in 1994.


“We have to work to reconstruct the center-right, and reconstructing it means having a big center-right party,” not a divided one, Alfano said.


He added that Berlusconi didn’t say one way or another if he would run himself. “It’s his choice,” he said. “If there are any decisions in this regard, he’ll be the one to say so.”


___


Follow Nicole Winfield at www.twitter.com/nwinfield


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Microsoft’s next-gen Xbox again said to launch ahead of 2013 holidays












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Lindsay Lohan risks return to jail after double trouble












NEW YORK/LOS ANGELES (Reuters) – Lindsay Lohan on Thursday faced the possibility of being sent back to jail after a tumultuous 24 hours in which she was arrested in New York for assault, and charged in California with reckless driving and lying to police over a June car crash.


Lohan, 26, who has been to rehab, jail and court multiple times since a 2007 arrest for drunk driving and cocaine possession, is still on unsupervised probation in Los Angeles for a 2011 jewelry theft.












But prosecutors in Santa Monica, California, said in a statement on Thursday that the “Mean Girls” actress lied to police when she told them she was not at the wheel of her Porsche when it smashed into a truck on a busy highway in the summer.


They charged Lohan with three misdemeanor counts stemming from that collision, hours after the troubled starlet was arrested on suspicion of punching a woman in the face at a Manhattan nightclub.


Lohan’s New York attorney Mark Heller said the actress was “a victim of someone trying to capture their 15 minutes of fame.”


“From my initial investigation, I am completely confident that this case will be concluded favorably and that Lindsay will be completely exonerated,” Heller said in a statement on the nightclub incident.


Frank Mateljan of the Los Angeles City Attorney‘s office, which handled the 2011 jewelry case, said prosecutors were still awaiting paperwork from New York and Santa Monica to determine if they will pursue a probation violation case against Lohan.


A Los Angeles judge told Lohan in March that she must obey all rules until 2014, and advised her to stop night-clubbing and focus on her work.


The two incidents came during a rough week for the former “Parent Trap” child star, who was once considered one of the most promising young actresses in Hollywood.


Her comeback performance on Sunday as screen legend Elizabeth Taylor in the TV movie “Liz & Dick,” was panned by critics and watched by a disappointingly small U.S. TV audience of 3.5 million.


In New York, Lohan was briefly arrested shortly after 4 a.m. (0900 GMT) on Thursday on a third-degree misdemeanor assault charge against a 28-year-old woman, police said. The victim suffered minor injuries, New York Police Sergeant John Buthorn said.


Celebrity website TMZ.com said Lohan had been drinking heavily and lashed out in a stand-off over one of the members of British boy band The Wanted, who were also at the club after playing a concert in New York.


Lohan’s recent visits to New York have featured run-ins with police and public spats over the last three months.


In October, police were called to the Long Island home of Lohan’s mother, Dina, after a loud argument, though no arrests were made. In September, Lohan was arrested in Manhattan after a pedestrian told police her car had struck him in an alley, but charges were not filed.


(Reporting by Colleen Jenkins in New York and Jill Serjeant in Los Angeles; Editing by Xavier Briand and Eric Walsh)


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Geithner predicts Republicans will accept higher tax rates












WASHINGTON (Reuters) – Treasury Secretary Timothy Geithner pressed Republicans to offer a plan to increase revenues and cut government spending, and predicted they would agree to raise tax rates on the wealthiest to secure a deal by year-end to avoid the “fiscal cliff.”


In a blitz of appearances on five Sunday morning talk shows, Geithner insisted that tax rates on the richest needed to go up in order to reach a deal, a step Republicans have so far resisted, and he dismissed much of the contentious rhetoric from last week as “political theater.”












“The only thing standing in the way of would be a refusal by Republicans to accept that rates are going to have to go up on the wealthiest Americans. And I don’t really see them doing that,” Geithner, who is leading the Obama administration‘s fiscal cliff negotiations, said on NBC’s “Meet the Press.”


The comments mark the latest round of high-stakes gamesmanship focusing on whether to extend the temporary tax cuts that originated under former President George W. Bush beyond their December 31 expiration date for all taxpayers, as Republicans want, or just for those with incomes under $ 250,000, as President Barack Obama and his fellow Democrats want.


Republicans, who control the House of Representatives but are the minority in the Senate, have expressed a willingness to raise revenues by taking steps such a limiting tax deductions, but they have largely held the line on increasing rates.


A handful of House Republicans expressed flexibility beyond that of their party leaders about considering an increase in tax rates for the wealthiest, as long as they are accompanied by significant spending cuts.


But most House Republicans refuse to back higher rates, preferring to raise revenue through tax reform.


“There’s not going to be an agreement without rates heading up,” Geithner said bluntly on CNN’s “State of the Union.”


The scheduled expiration of the Bush-era tax cuts and automatic reductions government spending set to take hold early next year would suck about $ 600 billion out of the economy and could spark a recession. The Obama administration and Congress are engaged in talks to avoid the fiscal cliff with a less-drastic plan to reduce U.S. budget deficits.


WHO SHOULD PAY?


Geithner’s Sunday interviews are part of a broader push to build public support for the Democrats’ position in the negotiations. Obama has made campaign-style appearances, including visiting a Pennsylvania toy factory on Friday where he portrayed Republicans as scrooges at Christmas time.


While breaking no new ground on the Obama administration’s position on Sunday, Geithner repeatedly urged Republicans to provide their own plan.


“They said they’re prepared to raise revenues but haven’t said how, or how much, or who should pay,” Geithner said on NBC.


In an interview with the Wall Street Journal on Friday, the Republican leader in the Senate, Mitch McConnell of Kentucky, asked Democrats to accept an increase in the Medicare eligibility age, impose higher Medicare premiums for the wealthy, and slow cost-of-living increases for Social Security.


At least one of those suggestions appears to have White House support. On CNN, Geithner said the administration‘s proposal included a modest rise in premiums for higher-income Medicare beneficiaries.


“What we can’t do is sit here trying to figure out what works for them,” Geithner said. “The ball really is with them now.”


The administration has said it is willing to find savings in the Medicare and Medicaid healthcare programs for the elderly and poor, but Geithner reiterated in an interview with ABC’s “This Week” that it would only be open to looking at changes in the Social Security retirement program outside of the context of a fiscal cliff deal.


(Reporting By Aruna Viswanatha; Editing by Eric Beech)


Seniors/Aging News Headlines – Yahoo! News


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7 missing in collapse of highway tunnel in Japan

TOKYO (AP) — At least seven people were feared missing and several dead after about 150 concrete panels fell from the roof of a tunnel on the main highway linking Tokyo with central Japan.

Efforts to rescue any survivors trapped inside the tunnel were hindered by heavy smoke after one vehicle caught fire inside the Sasago Tunnel, about 80 kilometers (50 miles) outside Tokyo.

Rescuers also temporarily suspended work because of fears of a further collapse. They were attempting to reach at least several vehicles believed buried in the rubble, including a truck whose driver was trapped inside and had called his company for help.

"I could hear voices of people calling for help, but the fire was just too strong," said a woman interviewed by public broadcaster NHK after she escaped from the tunnel.

The Fire and Disaster Management Agency issued a statement late Sunday saying five people were confirmed to have been in a car that burned inside the tunnel, and at least one other was in a truck. However, officials said they could not confirm the exact number of people believed dead.

Executives for Central Japan Expressway Co. said the company was investigating why the concrete panels had given way. A check of the 4.7-kilometer (3-mile) tunnel's roof in September and October found nothing amiss, they said.

It said two people were confirmed hurt, but the injuries were not severe.

The tunnel, which opened in 1977, is one of many in mountainous Japan. The location of the collapse, about 1.7 kilometers (a mile) inside the tunnel, was complicating rescue efforts, reports said.

Police vehicles, fire trucks and ambulances were massed outside the tunnel's entrance.

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